RELATIVE DOSING OF PHOSPHATE BINDERS FOR EFFECTIVE MANAGEMENT OF PHOSPHATE AND PROTEIN INTAKE IN CHRONIC KIDNEY DISEASE
نویسندگان
چکیده
منابع مشابه
Con: Phosphate binders in chronic kidney disease.
Phosphate binders are prescribed to chronic kidney disease (CKD) patients based on associations of serum phosphate concentrations with mortality and calcification, experimental evidence for direct calcifying effects of phosphate on vascular smooth muscle tissue and the central importance of phosphate retention in CKD-mineral and bone disorder (CKD-MBD). Current knowledge regarding phosphate met...
متن کاملUse of phosphate binders in chronic kidney disease.
PURPOSE OF REVIEW Hyperphosphatemia is a paradigmatic finding in late-stage chronic kidney disease (CKD) and consistently associated with adverse outcomes. Preclinical and epidemiological studies strongly support a causative role of hyperphosphatemia for cardiovascular complications, especially with regard to vascular, valvular and soft-tissue calcifications, and for subsequent mortality. There...
متن کاملSalivary phosphate secretion in chronic kidney disease.
BACKGROUND Hyperphosphatemia is an important contributor to cardiovascular calcification in chronic renal failure (CRF) patients. Cardiovascular calcifications are responsible for the high morbidity and mortality in patients undergoing hemodialysis (HD). Despite dietary phosphate reduction and treatment with phosphate binders, serum phosphorus level, as recommended by K/DOQI guidelines, is achi...
متن کاملEffect of dietary phosphate intake on the circadian rhythm of serum phosphate concentrations in chronic kidney disease: a crossover study.
BACKGROUND Previous trials of binders in chronic kidney disease (CKD) stages 3-5 have shown only modest changes in serum phosphate but evaluated morning phosphate. It is unknown whether a circadian pattern of phosphate concentrations exists in CKD and is modifiable by dietary manipulation. OBJECTIVES We determined the circadian pattern of serum phosphate concentrations in CKD and whether it w...
متن کاملOral phosphate binders in patients with kidney failure.
From the Departments of Medicine (M.T., N.P.) and Public Health Sciences (M.T.) and the Division of Critical Care Medicine (N.P.), University of Alberta, Edmonton; and the Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, AB (B.M.) — both in Canada. Address reprint requests to Dr. Tonelli at 7-129 Clinical Science Bldg., 8440 112th St., Edmonton, AB T6B 2G3,...
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ژورنال
عنوان ژورنال: Kidney Research and Clinical Practice
سال: 2012
ISSN: 2211-9132
DOI: 10.1016/j.krcp.2012.04.623